Cardiac Intraventricular Thrombus in Protein C Deficiency

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[Protein C deficiency].

Severe protein C deficiency (i.e. protein C activity <1 IU dL(-1)) is a rare autosomal recessive disorder that usually presents in the neonatal period with purpura fulminans (PF) and severe disseminated intravascular coagulation (DIC), often with concomitant venous thromboembolism (VTE). Recurrent thrombotic episodes (PF, DIC, or VTE) are common. Homozygotes and compound heterozygotes often pos...

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intraventricular hemorrhage in a term neonate: manifestation of protein s deficiency- a case report

protein s (ps) is an antithrombotic plasma protein that plays essential roles in limiting thrombus formation in the anticoagulant system. protein s deficiency is related with recurrent thrombosis. here, the authors report a case of a term neonate with severe ps deficiency in year 2015, imam hospital, tehran, iran, that had seizures and intraventricular hemorrhage (ivh) since the age of 3 days. ...

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Anti-protein C monoclonal antibody induces thrombus in mice.

Protein C (PC) is considered to be an important regulator of blood coagulation and fibrinolysis. During the production of monoclonal antibodies (MoAbs) against human PC in mouse ascitic fluid, one hybridoma was found to induce heavy thrombus in mice, resulting in severe hemorrhage. Intravenous infusion of the purified MoAb (PC01) from this hybridoma also caused thrombosis in mice. The crossreac...

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Protein C deficiency in liver disease.

Protein C is a vitamin K-dependent zymogen of a serine protease that is found in blood plasma. The active form, activated protein C, can inhibit blood coagulation and stimulate fibrinolysis. Protein C is synthesized in the liver as a single chain protein. Its synthesis requires several post-translational modifications including carboxylation of glutamic acid residues, hydroxylation of aspartic ...

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Erythropoietin (EPO) is a hemopoietic hormone, which controls erythropoiesis, produced by the renal interstitium in response to hypoxia (1). Furthermore, erythropoietin receptors were found on endothelial cells, fibroblasts and cardiomyocytes (1). Erythropoietin was associated with significant reduction in infarct size and apoptosis, improvement in ischemia-induced neovascularization and increa...

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ژورنال

عنوان ژورنال: Journal of the Royal Society of Medicine

سال: 2002

ISSN: 0141-0768,1758-1095

DOI: 10.1177/014107680209500821